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Probing the Structure and Electrostatics of Ion-Channel Pores One Proton at a Time
Although membrane proteins often rely on ionizable residues for structure and function, their ionization states under physiological conditions largely elude experimental estimation. To gain insight into the effect of the local microenvironment on the proton affinity of ionizable residues, we enginee...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1384014/ https://ncbi.nlm.nih.gov/pubmed/16355215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature04293 |
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