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Identifying the elusive link between amino acid sequence and charge selectivity in pentameric ligand-gated ion channels

Among neurotransmitter-gated ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique in that its members display opposite permeant-ion charge selectivities despite sharing the same structural fold. Although much effort has been devoted to the identification of the me...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Cymes, Gisela D., Grosman, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111664/
https://ncbi.nlm.nih.gov/pubmed/27791102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608519113
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