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Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer

The lipid dependence of the nicotinic acetylcholine receptor from the Torpedo electric organ has long been recognized, and one of the most consistent experimental observations is that, when reconstituted in membranes formed by zwitterionic phospholipids alone, exposure to agonist fails to elicit ion...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kumar, Pramod, Wang, Yuhang, Zhang, Zhening, Zhao, Zhiyu, Cymes, Gisela D., Tajkhorshid, Emad, Grosman, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983364/
https://ncbi.nlm.nih.gov/pubmed/31911476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906823117
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