Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer

The lipid dependence of the nicotinic acetylcholine receptor from the Torpedo electric organ has long been recognized, and one of the most consistent experimental observations is that, when reconstituted in membranes formed by zwitterionic phospholipids alone, exposure to agonist fails to elicit ion...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kumar, Pramod, Wang, Yuhang, Zhang, Zhening, Zhao, Zhiyu, Cymes, Gisela D., Tajkhorshid, Emad, Grosman, Claudio
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983364/
https://ncbi.nlm.nih.gov/pubmed/31911476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906823117
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