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Identifying the elusive link between amino acid sequence and charge selectivity in pentameric ligand-gated ion channels

Among neurotransmitter-gated ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique in that its members display opposite permeant-ion charge selectivities despite sharing the same structural fold. Although much effort has been devoted to the identification of the me...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Cymes, Gisela D., Grosman, Claudio
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5111664/
https://ncbi.nlm.nih.gov/pubmed/27791102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608519113
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