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Gα(q) binds to p110α/p85α phosphoinositide 3-kinase and displaces Ras
Several studies have reported that activation of G(q)-coupled receptors inhibits PI3K (phosphoinositide 3-kinase) signalling. In the present study, we used purified proteins to demonstrate that Gα(q) directly inhibits p110α/p85α PI3K in a GTP-dependent manner. Activated Gα(q) binds to the p110α/p85α...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Portland Press Ltd.
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383705/ https://ncbi.nlm.nih.gov/pubmed/16268778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051493 |
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