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Gα(q) binds to p110α/p85α phosphoinositide 3-kinase and displaces Ras

Several studies have reported that activation of G(q)-coupled receptors inhibits PI3K (phosphoinositide 3-kinase) signalling. In the present study, we used purified proteins to demonstrate that Gα(q) directly inhibits p110α/p85α PI3K in a GTP-dependent manner. Activated Gα(q) binds to the p110α/p85α...

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Detalhes bibliográficos
Main Authors: Ballou, Lisa M., Chattopadhyay, Mohar, Li, Yan, Scarlata, Suzanne, Lin, Richard Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383705/
https://ncbi.nlm.nih.gov/pubmed/16268778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051493
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