Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

Class IA phosphoinositide 3-kinases (PI3Ks) signal downstream of tyrosine kinases and Ras and control a wide variety of biological responses. In mammals, these heterodimeric PI3Ks consist of a p110 catalytic subunit (p110α, p110β, or p110δ) bound to any of five distinct regulatory subunits (p85α, p8...

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Detalhes bibliográficos
Main Authors: Geering, Barbara, Cutillas, Pedro R., Nock, Gemma, Gharbi, Severine I., Vanhaesebroeck, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876529/
https://ncbi.nlm.nih.gov/pubmed/17470792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700373104
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