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Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase

Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110α, -β, -γ, and -δ. At physiological levels of expression, the wild-type p110α isoform lacks oncogenic potential, but gain-of-function mutations and overexpression of p110α are correlated with oncogenicity. The p11...

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Bibliografiske detaljer
Main Authors: Kang, Sohye, Denley, Adam, Vanhaesebroeck, Bart, Vogt, Peter K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360601/
https://ncbi.nlm.nih.gov/pubmed/16432180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510772103
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