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Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase
Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110α, -β, -γ, and -δ. At physiological levels of expression, the wild-type p110α isoform lacks oncogenic potential, but gain-of-function mutations and overexpression of p110α are correlated with oncogenicity. The p11...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1360601/ https://ncbi.nlm.nih.gov/pubmed/16432180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510772103 |
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