A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2

We recently described a CHO DSBR mutant belonging to the XRCC7 complementation group (XR-C2) that has the interesting phenotype of being radiosensitive, but having only a modest defect in VDJ recombination. This cell line expresses only slightly reduced levels of DNA-PKcs but has undetectable DNA-PK...

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Hlavní autoři: Woods, Timothy, Wang, Wei, Convery, Erin, Errami, Abdellatif, Zdzienicka, Malgorzata Z., Meek, Katheryn
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC137947/
https://ncbi.nlm.nih.gov/pubmed/12466535
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