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()Restoration of ATM expression in DNA-PKcs deficient cells inhibits signal end joining
Unlike most DNA-PKcs deficient mouse cell strains, we show here that targeted deletion of DNA-PKcs in two different human cell lines abrogates VDJ signal end joining in episomal assays. Although the mechanism is not well defined, DNA-PKcs deficiency results in spontaneous reduction of ATM expression...
Enregistré dans:
| Publié dans: | J Immunol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4799769/ https://ncbi.nlm.nih.gov/pubmed/26921311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501654 |
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