EXT-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas.

Osteochondromas occur as sporadic solitary lesions or as multiple lesions, characterizing the hereditary multiple exostoses syndrome (EXT). Approximately 15% of all chondrosarcomas arise within the cartilaginous cap of an osteochondroma. EXT is genetically heterogeneous, and two genes, EXT1 and EXT2...

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Main Authors: Bovée, J V, Cleton-Jansen, A M, Wuyts, W, Caethoven, G, Taminiau, A H, Bakker, E, Van Hul, W, Cornelisse, C J, Hogendoorn, P C
Format: Artigo
Language:Inglês
Published: 1999
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1377975/
https://ncbi.nlm.nih.gov/pubmed/10441575
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