The catalytic domain of RNase E shows inherent 3′ to 5′ directionality in cleavage site selection

RNase E, a multifunctional endoribonuclease of Escherichia coli, attacks substrates at highly specific sites. By using synthetic oligoribonucleotides containing repeats of identical target sequences protected from cleavage by 2′-O-methylated nucleotide substitutions at specific positions, we investi...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Feng, Yanan, Vickers, Timothy A., Cohen, Stanley N.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2002
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137490/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12417756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.202590899
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