Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage

Topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and meiosis and is a highly attractive target for chemotherapeutic agents. We have identified previously topoisomerase II and heat shock protein 90 (Hsp90) as part of a complex. In this paper we demonstra...

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Bibliographic Details
Main Authors: Barker, Catherine R., McNamara, Anne V., Rackstraw, Stephen A., Nelson, David E., White, Mike R., Watson, Alastair J. M., Jenkins, John R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1373695/
https://ncbi.nlm.nih.gov/pubmed/16504968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkj516
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