Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases
The potent anticancer drug actinomycin D (ActD) acts by binding to DNA GpC sequences, thereby interfering with essential biological processes including replication, transcription and topoisomerase. Certain neurological diseases are correlated with expansion of (CTG)(n) trinucleotide sequences, which...
Kaydedildi:
| Yayımlandı: | Nucleic Acids Res |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2002
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12433994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf619 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|