Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases

The potent anticancer drug actinomycin D (ActD) acts by binding to DNA GpC sequences, thereby interfering with essential biological processes including replication, transcription and topoisomerase. Certain neurological diseases are correlated with expansion of (CTG)(n) trinucleotide sequences, which...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Hou, Ming-Hon, Robinson, Howard, Gao, Yi-Gui, Wang, Andrew H.-J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2002
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12433994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf619
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