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Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases

The potent anticancer drug actinomycin D (ActD) acts by binding to DNA GpC sequences, thereby interfering with essential biological processes including replication, transcription and topoisomerase. Certain neurological diseases are correlated with expansion of (CTG)(n) trinucleotide sequences, which...

詳細記述

保存先:
書誌詳細
主要な著者: Hou, Ming-Hon, Robinson, Howard, Gao, Yi-Gui, Wang, Andrew H.-J.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC137167/
https://ncbi.nlm.nih.gov/pubmed/12433994
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