Nalaganje...
Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases
The potent anticancer drug actinomycin D (ActD) acts by binding to DNA GpC sequences, thereby interfering with essential biological processes including replication, transcription and topoisomerase. Certain neurological diseases are correlated with expansion of (CTG)(n) trinucleotide sequences, which...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137167/ https://ncbi.nlm.nih.gov/pubmed/12433994 |
| Oznake: |
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