Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo

We report the targeted mutagenesis of the murine iron regulatory protein (IRP)-1 and IRP2 genes, respectively, with a classical gene trap construct. Insertion of the targeting cassette into the second intron of either gene by homologous recombination interrupts their open reading frames near the N t...

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Bibliografiske detaljer
Main Authors: GALY, BRUNO, FERRING, DUNJA, BENESOVA, MONIKA, BENES, VLADIMIR, HENTZE, MATTHIAS W.
Format: Artigo
Sprog:Inglês
Udgivet: Copyright 2004 by RNA Society 2004
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370593/
https://ncbi.nlm.nih.gov/pubmed/15208438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7220704
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