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siRNA function in RNAi: A chemical modification analysis

Various chemical modifications were created in short-interfering RNAs (siRNAs) to determine the biochemical properties required for RNA interference (RNAi). Remarkably, modifications at the 2′-position of pentose sugars in siRNAs showed the 2′-OHs were not required for RNAi, indicating that RNAi mac...

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Hlavní autoři: CHIU, YA-LIN, RANA, TARIQ M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Copyright 2003 by RNA Society 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370469/
https://ncbi.nlm.nih.gov/pubmed/12923253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5103703
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