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siRNA function in RNAi: A chemical modification analysis
Various chemical modifications were created in short-interfering RNAs (siRNAs) to determine the biochemical properties required for RNA interference (RNAi). Remarkably, modifications at the 2′-position of pentose sugars in siRNAs showed the 2′-OHs were not required for RNAi, indicating that RNAi mac...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Copyright 2003 by RNA Society
2003
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370469/ https://ncbi.nlm.nih.gov/pubmed/12923253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5103703 |
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