Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.

Generally, mRNAs that prematurely terminate translation are abnormally low in abundance. In the case of mammalian cells, nonsense codons most often mediate a reduction in the abundance of newly synthesized, nucleus-associated mRNA by a mechanism that is not well understood. With the aim of defining...

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Библиографические подробности
Главные авторы: Zhang, J, Sun, X, Qian, Y, Maquat, L E
Формат: Artigo
Язык:Inglês
Опубликовано: 1998
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369660/
https://ncbi.nlm.nih.gov/pubmed/9671053
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