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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position
mRNA for glutathione peroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocysteine (Sec) codon is recognized as nonsense. Here, we demonstrate by moving the sole intron of the GPx1 gene that either the Sec codon or a TAA codon in its place elicits NMD when l...
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| Päätekijät: | , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2000
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302051/ https://ncbi.nlm.nih.gov/pubmed/10970865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4734 |
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