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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position

mRNA for glutathione peroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocysteine (Sec) codon is recognized as nonsense. Here, we demonstrate by moving the sole intron of the GPx1 gene that either the Sec codon or a TAA codon in its place elicits NMD when l...

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Detalhes bibliográficos
Main Authors: Sun, Xiaolei, Moriarty, Patrick M., Maquat, Lynne E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC302051/
https://ncbi.nlm.nih.gov/pubmed/10970865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4734
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