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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position
mRNA for glutathione peroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocysteine (Sec) codon is recognized as nonsense. Here, we demonstrate by moving the sole intron of the GPx1 gene that either the Sec codon or a TAA codon in its place elicits NMD when l...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2000
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC302051/ https://ncbi.nlm.nih.gov/pubmed/10970865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4734 |
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