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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position

mRNA for glutathione peroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocysteine (Sec) codon is recognized as nonsense. Here, we demonstrate by moving the sole intron of the GPx1 gene that either the Sec codon or a TAA codon in its place elicits NMD when l...

詳細記述

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書誌詳細
主要な著者: Sun, Xiaolei, Moriarty, Patrick M., Maquat, Lynne E.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC302051/
https://ncbi.nlm.nih.gov/pubmed/10970865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4734
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