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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position

mRNA for glutathione peroxidase 1 (GPx1) is subject to cytoplasmic nonsense-mediated decay (NMD) when the UGA selenocysteine (Sec) codon is recognized as nonsense. Here, we demonstrate by moving the sole intron of the GPx1 gene that either the Sec codon or a TAA codon in its place elicits NMD when l...

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Bibliografiska uppgifter
Huvudupphovsmän: Sun, Xiaolei, Moriarty, Patrick M., Maquat, Lynne E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2000
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC302051/
https://ncbi.nlm.nih.gov/pubmed/10970865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.17.4734
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