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At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

Mammalian cells have established mechanisms to reduce the abundance of mRNAs that harbor a nonsense codon and prematurely terminate translation. In the case of the human triosephosphate isomerase (TPI gene), nonsense codons located less than 50 to 55 bp upstream of intron 6, the 3′-most intron, fail...

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Udgivet i:Mol Cell Biol
Principais autores: Zhang, Jing, Sun, Xiaolei, Qian, Yimei, LaDuca, Jeffrey P., Maquat, Lynne E.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109113/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710612/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.9.5272
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