At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

Mammalian cells have established mechanisms to reduce the abundance of mRNAs that harbor a nonsense codon and prematurely terminate translation. In the case of the human triosephosphate isomerase (TPI gene), nonsense codons located less than 50 to 55 bp upstream of intron 6, the 3′-most intron, fail...

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Main Authors: Zhang, Jing, Sun, Xiaolei, Qian, Yimei, LaDuca, Jeffrey P., Maquat, Lynne E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
Assuntos:
Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC109113/
https://ncbi.nlm.nih.gov/pubmed/9710612
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