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At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

Mammalian cells have established mechanisms to reduce the abundance of mRNAs that harbor a nonsense codon and prematurely terminate translation. In the case of the human triosephosphate isomerase (TPI gene), nonsense codons located less than 50 to 55 bp upstream of intron 6, the 3′-most intron, fail...

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Published in:Mol Cell Biol
Main Authors: Zhang, Jing, Sun, Xiaolei, Qian, Yimei, LaDuca, Jeffrey P., Maquat, Lynne E.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1998
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109113/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710612/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.9.5272
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