At Least One Intron Is Required for the Nonsense-Mediated Decay of Triosephosphate Isomerase mRNA: a Possible Link between Nuclear Splicing and Cytoplasmic Translation

Mammalian cells have established mechanisms to reduce the abundance of mRNAs that harbor a nonsense codon and prematurely terminate translation. In the case of the human triosephosphate isomerase (TPI gene), nonsense codons located less than 50 to 55 bp upstream of intron 6, the 3′-most intron, fail...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Zhang, Jing, Sun, Xiaolei, Qian, Yimei, LaDuca, Jeffrey P., Maquat, Lynne E.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1998
Materias:	Gene Expression
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109113/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710612/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.9.5272
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