The Simian Immunodeficiency Virus Δnef Vaccine, after Application to the Tonsils of Rhesus Macaques, Replicates Primarily within CD4(+) T Cells and Elicits a Local Perforin-Positive CD8(+) T-Cell Response

Deletion of the nef gene from simian immunodeficiency virus (SIV) strain SIVmac239 yields a virus that undergoes attenuated growth in rhesus macaques and offers substantial protection against a subsequent challenge with some SIV wild-type viruses. We used a recently described model to identify sites...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Stahl-Hennig, Christiane, Steinman, Ralph M., Ten Haaft, Peter, Überla, Klaus, Stolte, Nicole, Saeland, Sem, Tenner-Racz, Klara, Racz, Paul
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Pathogenesis and Immunity
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136843/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11752159/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.2.688-696.2002
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