Structure of Core Domain of Fibril-Forming PHF/Tau Fragments

Short peptide sequences within the microtubule binding domain of the protein Tau are proposed to be core nucleation sites for formation of amyloid fibrils displaying the paired helical filament (PHF) morphology characteristic of neurofibrillary tangles. To study the structure of these proposed nucle...

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Bibliografske podrobnosti
Main Authors: Inouye, Hideyo, Sharma, Deepak, Goux, Warren J., Kirschner, Daniel A.
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2006
Teme:
Supramolecular Assemblies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367326/
https://ncbi.nlm.nih.gov/pubmed/16339876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.070136
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