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Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
The self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer’s disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Oxidative stress, which accompanies AD, induces multip...
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| Publicado no: | Cells |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8005035/ https://ncbi.nlm.nih.gov/pubmed/33809978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10030703 |
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