Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain

The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble intracellular deposits central to the development of Alzheimer’s disease (AD) and other tauopathies. Full‐length tau requires the addition of anionic cofactors such as heparin to enhance assembly. We have shown...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Al‐Hilaly, Youssra K., Foster, Bronwen E., Biasetti, Luca, Lutter, Liisa, Pollack, Saskia J., Rickard, Janet E., Storey, John M. D., Harrington, Charles R., Xue, Wei‐Feng, Wischik, Claude M., Serpell, Louise C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Letters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078754/
https://ncbi.nlm.nih.gov/pubmed/31721178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13675
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