Paired Helical Filament-Forming Region of Tau (297–391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells

Assembly of tau protein into paired helical filaments and straight filaments is a key feature of Alzheimer's disease. Aggregation of tau has been implicated in neurodegeneration, cellular toxicity and the propagation, which accompanies disease progression. We have reported previously that a reg...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Pollack, Saskia J., Trigg, Jasmine, Khanom, Tahmida, Biasetti, Luca, Marshall, Karen E., Al-Hilaly, Youssra K., Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427330/
https://ncbi.nlm.nih.gov/pubmed/32681841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.05.027
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