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Predicting the Tolerance of Proteins to Random Amino Acid Substitution

We have recently proposed a thermodynamic model that predicts the tolerance of proteins to random amino acid substitutions. Here we test this model against extensive simulations with compact lattice proteins, and find that the overall performance of the model is very good. We also derive an approxim...

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Detalhes bibliográficos
Main Authors: Wilke, Claus O., Bloom, Jesse D., Drummond, D. Allan, Raval, Alpan
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366941/
https://ncbi.nlm.nih.gov/pubmed/16150971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.062125
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