Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells

The human papillomavirus (HPV) type 16 E7 oncoprotein must inactivate the retinoblastoma tumor suppressor (Rb) pathway to bypass G(1) arrest. However, E7 C-terminal mutants that were able to inactivate Rb were unable to bypass DNA damage-induced G(1) arrest and keratinocyte senescence, suggesting th...

Ful tanımlama

Detaylı Bibliyografya

Yayımlandı:	J Virol
Asıl Yazarlar:	Helt, Anna-Marija, Funk, Jens Oliver, Galloway, Denise A.
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology (ASM) 2002
Konular:	Transformation and Oncogenesis
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12239337/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.20.10559-10568.2002
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!