Inactivation of both the Retinoblastoma Tumor Suppressor and p21 by the Human Papillomavirus Type 16 E7 Oncoprotein Is Necessary To Inhibit Cell Cycle Arrest in Human Epithelial Cells

The human papillomavirus (HPV) type 16 E7 oncoprotein must inactivate the retinoblastoma tumor suppressor (Rb) pathway to bypass G(1) arrest. However, E7 C-terminal mutants that were able to inactivate Rb were unable to bypass DNA damage-induced G(1) arrest and keratinocyte senescence, suggesting th...

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Bibliografski detalji

Izdano u:	J Virol
Glavni autori:	Helt, Anna-Marija, Funk, Jens Oliver, Galloway, Denise A.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2002
Teme:	Transformation and Oncogenesis
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12239337/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.20.10559-10568.2002
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