Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7

The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired duri...

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Hlavní autoři: Gonzalez, Sonia L., Stremlau, Matt, He, Xi, Basile, John R., Münger, Karl
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Transformation and Oncogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC114993/
https://ncbi.nlm.nih.gov/pubmed/11462030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.16.7583-7591.2001
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