Degradation of the Retinoblastoma Tumor Suppressor by the Human Papillomavirus Type 16 E7 Oncoprotein Is Important for Functional Inactivation and Is Separable from Proteasomal Degradation of E7

The steady-state level and metabolic half-life of retinoblastoma tumor suppressor protein pRB are decreased in cells that express high-risk human papillomavirus (HPV) E7 proteins. Here we show that pRB degradation is a direct activity of E7 and does not reflect a property of cell lines acquired duri...

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Pubblicato in:	J Virol
Autori principali:	Gonzalez, Sonia L., Stremlau, Matt, He, Xi, Basile, John R., Münger, Karl
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Transformation and Oncogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11462030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.16.7583-7591.2001
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