Destabilization of the Retinoblastoma Tumor Suppressor by Human Papillomavirus Type 16 E7 Is Not Sufficient To Overcome Cell Cycle Arrest in Human Keratinocytes

The E7 oncoprotein of human papillomavirus type 16 promotes cell proliferation in the presence of antiproliferative signals. Mutagenesis of E7 has revealed that this activity requires three regions, conserved regions 1 and 2 and a C-terminal zinc finger. Binding to the retinoblastoma tumor repressor...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Helt, Anna-Marija, Galloway, Denise A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Transformation and Oncogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114400/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11435552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.15.6737-6747.2001
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