Replacement of the P1 Amino Acid of Human Immunodeficiency Virus Type 1 Gag Processing Sites Can Inhibit or Enhance the Rate of Cleavage by the Viral Protease

Processing of the human immunodeficiency virus type 1 (HIV-1) Gag precursor is highly regulated, with differential rates of cleavage at the five major processing sites to give characteristic processing intermediates. We examined the role of the P1 amino acid in determining the rate of cleavage at ea...

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Bibliographic Details
Main Authors: Pettit, Steve C., Henderson, Gavin J., Schiffer, Celia A., Swanstrom, Ronald
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC136535/
https://ncbi.nlm.nih.gov/pubmed/12239298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10226-10233.2002
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