The Dimer Interfaces of Protease and Extra-Protease Domains Influence the Activation of Protease and the Specificity of GagPol Cleavage

Activation of the human immunodeficiency virus type 1 (HIV-1) protease is an essential step in viral replication. As is the case for all retroviral proteases, enzyme activation requires the formation of protease homodimers. However, little is known about the mechanisms by which retroviral proteases...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Pettit, Steven C., Gulnik, Sergei, Everitt, Lori, Kaplan, Andrew H.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Structure and Assembly
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140564/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12477841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.1.366-374.2003
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