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The Dimer Interfaces of Protease and Extra-Protease Domains Influence the Activation of Protease and the Specificity of GagPol Cleavage

Activation of the human immunodeficiency virus type 1 (HIV-1) protease is an essential step in viral replication. As is the case for all retroviral proteases, enzyme activation requires the formation of protease homodimers. However, little is known about the mechanisms by which retroviral proteases...

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Main Authors: Pettit, Steven C., Gulnik, Sergei, Everitt, Lori, Kaplan, Andrew H.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2003
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC140564/
https://ncbi.nlm.nih.gov/pubmed/12477841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.366-374.2003
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