Replacement of the P1 Amino Acid of Human Immunodeficiency Virus Type 1 Gag Processing Sites Can Inhibit or Enhance the Rate of Cleavage by the Viral Protease

Processing of the human immunodeficiency virus type 1 (HIV-1) Gag precursor is highly regulated, with differential rates of cleavage at the five major processing sites to give characteristic processing intermediates. We examined the role of the P1 amino acid in determining the rate of cleavage at ea...

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Detalhes bibliográficos
Main Authors: Pettit, Steve C., Henderson, Gavin J., Schiffer, Celia A., Swanstrom, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136535/
https://ncbi.nlm.nih.gov/pubmed/12239298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.20.10226-10233.2002
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