Crystal Structures of Zidovudine- or Lamivudine-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptases Containing Mutations at Codons 41, 184, and 215

Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal conformational changes in the polymerase or nonnuc...

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Hlavní autoři: Chamberlain, P. P., Ren, J., Nichols, C. E., Douglas, L., Lennerstrand, J., Larder, B. A., Stuart, D. I., Stammers, D. K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC136500/
https://ncbi.nlm.nih.gov/pubmed/12208978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.19.10015-10019.2002
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