Crystal Structures of Zidovudine- or Lamivudine-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptases Containing Mutations at Codons 41, 184, and 215

Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal conformational changes in the polymerase or nonnuc...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Chamberlain, P. P., Ren, J., Nichols, C. E., Douglas, L., Lennerstrand, J., Larder, B. A., Stuart, D. I., Stammers, D. K.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Vaccines and Antiviral Agents
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12208978/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.19.10015-10019.2002
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