Crystal Structures of Zidovudine- or Lamivudine-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptases Containing Mutations at Codons 41, 184, and 215

Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal conformational changes in the polymerase or nonnuc...

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Bibliographic Details
Main Authors: Chamberlain, P. P., Ren, J., Nichols, C. E., Douglas, L., Lennerstrand, J., Larder, B. A., Stuart, D. I., Stammers, D. K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC136500/
https://ncbi.nlm.nih.gov/pubmed/12208978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.19.10015-10019.2002
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