Mutation of the Catalytic Domain of the Foamy Virus Reverse Transcriptase Leads to Loss of Processivity and Infectivity

Foamy virus (FV) replication is resistant to most nucleoside analog reverse transcriptase (RT) inhibitors. In an attempt to create a 2′,3′-dideoxy-3′-thiacytidine (3TC)-sensitive virus, the second residue in the highly conserved YXDD motif of simian foamy virus-chimpanzee (human isolate) [SFVcpz(hu)...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Rinke, Carolyn S., Boyer, Paul L., Sullivan, Mark D., Hughes, Stephen H., Linial, Maxine L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136390/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12097569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.15.7560-7570.2002
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