Mutation of the Catalytic Domain of the Foamy Virus Reverse Transcriptase Leads to Loss of Processivity and Infectivity

Foamy virus (FV) replication is resistant to most nucleoside analog reverse transcriptase (RT) inhibitors. In an attempt to create a 2′,3′-dideoxy-3′-thiacytidine (3TC)-sensitive virus, the second residue in the highly conserved YXDD motif of simian foamy virus-chimpanzee (human isolate) [SFVcpz(hu)...

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Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Rinke, Carolyn S., Boyer, Paul L., Sullivan, Mark D., Hughes, Stephen H., Linial, Maxine L.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2002
Sujets:	Replication
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136390/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12097569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.15.7560-7570.2002
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