Mutation of the Catalytic Domain of the Foamy Virus Reverse Transcriptase Leads to Loss of Processivity and Infectivity

Foamy virus (FV) replication is resistant to most nucleoside analog reverse transcriptase (RT) inhibitors. In an attempt to create a 2′,3′-dideoxy-3′-thiacytidine (3TC)-sensitive virus, the second residue in the highly conserved YXDD motif of simian foamy virus-chimpanzee (human isolate) [SFVcpz(hu)...

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Pubblicato in:	J Virol
Autori principali:	Rinke, Carolyn S., Boyer, Paul L., Sullivan, Mark D., Hughes, Stephen H., Linial, Maxine L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136390/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12097569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.15.7560-7570.2002
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