Mutation of the Catalytic Domain of the Foamy Virus Reverse Transcriptase Leads to Loss of Processivity and Infectivity
Foamy virus (FV) replication is resistant to most nucleoside analog reverse transcriptase (RT) inhibitors. In an attempt to create a 2′,3′-dideoxy-3′-thiacytidine (3TC)-sensitive virus, the second residue in the highly conserved YXDD motif of simian foamy virus-chimpanzee (human isolate) [SFVcpz(hu)...
Guardat en:
| Publicat a: | J Virol |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136390/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12097569/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.15.7560-7570.2002 |
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