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Downregulation of uPAR and Cathepsin B Retards Cofilin Dephosphorylation

Cathepsin B and uPAR play key roles in cancer cell migration and invasion. Here, we demonstrate that the simultaneous, siRNA-mediated downregulation of uPAR and cathepsin B inhibits glioma cell migration and is accompanied by cytoskeletal condensation. We show that the dephosphorylation of cofilin i...

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Detalhes bibliográficos
Main Authors: Gondi, Christopher S., Kandhukuri, Neelima, Kondraganti, Shakuntala, Gujrati, Meena, Olivero, William C., Dinh, Dzung H., Rao, Jasti S
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1363688/
https://ncbi.nlm.nih.gov/pubmed/16465367
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