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Intraperitoneal Injection of an hpRNA-expressing Plasmid Targeting uPAR and uPA Retards Angiogenesis and Inhibits Intracranial Tumor Growth in Nude Mice

PURPOSE: The purpose of this study was to evaluate the therapeutic potential of using plasmid expressed RNAi targeting uPAR and uPA to treat human glioma. EXPERIMENTAL DESIGN: In the present study, we have used plasmid based RNAi to simultaneously downregulate the expression of uPAR and uPA in SNB19...

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Main Authors: Gondi, Christopher S., Lakka, Sajani S., Dinh, Dzung H., Olivero, William C., Gujrati, Meena, Rao, Jasti S
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2139987/
https://ncbi.nlm.nih.gov/pubmed/17634529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-06-3032
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