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Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines.

In our earlier reports, we showed that downregulation of uPA and uPAR inhibited glioma tumor angiogenesis in SNB19 cells, and intraperitoneal injection of a hairpin shRNA expressing plasmid targeting uPA and uPAR inhibited angiogenesis in nude mice. The exact mechanism by which inhibition of angioge...

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Detalhes bibliográficos
Main Authors: Hari Raghu, Sajani S Lakka, Christopher S Gondi, Sanjeeva Mohanam, Dzung H Dinh, Meena Gujrati, Jasti S Rao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2010-08-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC2929192?pdf=render
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